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HPPSC Scientific Officer (NDPS) Syllabus – Complete Syllabus & Exam Pattern

HPPSC Scientific Officer (NDPS) Syllabus : The Himachal Pradesh Public Service Commission (HPPSC) has prescribed the syllabus for the Descriptive Subject Aptitude Test (SAT) for recruitment to the post of Scientific Officer (NDPS), Group-B in the Directorate of Forensic Services, Home Department, Himachal Pradesh.

The examination paper will have a duration of 3 hours and carry a maximum of 120 marks. The paper is divided into Part-I and Part-II, with each part carrying 60 marks.

The syllabus covers major areas of Forensic Science, Crime Scene Management, Dactylography, Instrumental Methods, Chemometrics, Research Methodology, Chemistry, Narcotic Drugs and Psychotropic Substances, Forensic Chemistry, Analytical Chemistry, Sample Preparation, Separation Techniques and Forensic Pharmacology.

HPPSC Scientific Officer (NDPS) Exam Pattern

Part-I Syllabus – 60 Marks

Unit-I: Forensic Science

• Definition, nature and scope of Forensic Science
• Forensic Science in India and abroad
• Forensic organizations including CFSLs, FSLs, DFSS, NCRB, FBI and INTERPOL
• History and development of Forensic Science
• Principles of Forensic Science
• Locard’s Exchange Principle
• Law of natural variation
• Law of comparison
• Law of probability
• Law of individualization
• Law of continuous change
• Sydney Declaration and seven principles
• Disciplines of Forensic Science
• Duties and responsibilities of forensic experts
• Frye’s and Daubert Standards
• Physical, digital and trace evidence
• Standard operating procedures for collection and preservation of evidence
• Applications of Artificial Intelligence and Machine Learning in Forensic Science

Unit-II: Crime Scene Management

• Systematic approach to crime scene investigation
• Securing the crime scene
• Identification, collection, packaging and forwarding of evidence
• Chain of custody
• Crime scene photography and videography
• 3D recording
• Sketching and preparation of notes
• Various search methods
• Crime scene reconstruction
• Importance and methodology of crime scene reconstruction
• Data collection, conjecture and hypothesis formulation
• Testing and theory formulation
• Crime scene reconstruction report and expert testimony
• Blood stain pattern analysis
• Biological and physical properties of blood
• Droplet formation and directionality
• Point of convergence and point of origin
• Impact spatter and its mechanism
• Road accident reconstruction
• Skid marks and determination of speed
• Evidence from victim, vehicle and crime scene
• Glass, soil, paint and impact analysis

Unit-III: Fundamentals of Dactylography

• History and development of fingerprints
• Formation of ridges
• Fingerprint pattern types and pattern areas
• Principles of fingerprint science
• Henry system of 10-digit classification
• Battley’s single digit classification
• Methods of recording fingerprints
• Development of fingerprints from crime scenes
• Photography of fingerprints
• Development of fingerprints from living and dead persons
• Comparison of fingerprints
• Class characteristics and individual characteristics
• Digital transmission of fingerprints
• National Automatic Fingerprint Identification System (NAFIS)
• Biometrics in person identification
• Face recognition, iris, retina and hand geometry

Unit-IV: Instrumental Methods

Microscopy:

• Simple, compound and comparison microscopy
• Fluorescence, polarized, stereo and infrared microscopy
• Scanning Electron Microscope
• Field Emission Scanning Electron Microscope
• Transmission Electron Microscope
• Scanning Probe Microscope
• Scanning Tunneling Electron Microscope (STEM)
• Atomic Force Microscope
• Quantum 3D Microscope
• Confocal Microscope
• Video Spectral Comparator (VSC)

Atomic Spectroscopy:

• Atomic Absorption Spectroscopy
• Graphite Furnace Atomic Spectroscopy
• Atomic Emission Spectroscopy
• Inductively Coupled Plasma Mass Spectroscopy

X-Ray Techniques:

• X-Ray Diffraction
• X-Ray Fluorescence – Energy and Wavelength Dispersion
• Auger Electron Spectrography (ESCA)

Molecular Spectroscopy:

• UV-Vis Spectroscopy
• IR Spectroscopy
• Fourier Transform Infrared Spectroscopy (FTIR)
• Raman Spectroscopy

Electrophoresis:

• Cross-over electrophoresis
• Agarose gel electrophoresis
• Polyacrylamide gel electrophoresis
• SDS electrophoresis
• Pulse field gel electrophoresis
• Capillary electrophoresis
• Immuno electrophoresis
• Iso-electric focusing

Chromatography:

• Thin Layer Chromatography (TLC)
• HPTLC
• Paper and Column Chromatography
• High Performance Liquid Chromatography (HPLC)

• Layered Voice Analysis (LVA)
• Brain Electrical Oscillation Signature (BEOS)
• Polygraph
• Brain mapping
• Narco-analysis
• Integrated Ballistic Identification System (IBIS)

Unit-V: Chemometrics and Quality Management

• Introduction to chemometrics
• Mean, Mode and Median
• Standard deviation and variance
• Coefficient of variation
• t square test
• Chi square test
• ANOVA test
• Application of statistical tools in data interpretation
• Multivariate analysis
• Principal Component Analysis (PCA)
• Partial Least Squares (PLS)
• Cluster analysis
• Discriminant analysis

Quality Management System:

• ISO/IEC 17025:2017
• ISO 21043
• ISO 9001
• Accreditation and certification
• Quality control and quality assurance
• Calibration
• Proficiency testing
• Blind testing
• Inter- and intra-laboratory comparison
• Internal audit
• Measurement uncertainty
• Z score
• Limit of Detection (LOD)
• Limit of Quantification (LOQ)
• Verification and validation methods

Unit-VI: Laboratory Information, Report Writing & Research Methodology

• Laboratory Information Management Systems (LIMS)
• Management and protection of laboratory data
• Traceability of records
• Transparency in laboratory operations
• Preparation of scientific test reports
• Essentials and admissibility of test reports
• Scene of crime reports
• Expert testimony
• Examination-in-chief
• Cross-examination
• Re-examination

Related Laws: BNS, BNSS, BSA 2023, IT Act 2000, POCSO Act, NDPS Act and MVA Act.

Research Methodology:

• Research design
• Hypothesis formulation
• Sampling
• Data collection techniques
• Statistical interpretation
• Literature review
• Scientific paper writing skills
• Types of plagiarism
• Plagiarism detection tools
• Ethical responsibilities in research and report preparation
• Citation index and impact factor
• Ethics in Forensic Science

Part-II Syllabus – 60 Marks

Unit-VII: Physical, Inorganic and Organic Chemistry

• Properties of alkanes, alkenes and alkynes
• Aromatic hydrocarbons
• Alcohols and phenols
• Carboxylic acids
• Aldehydes and ketones
• Amines and nitro compounds
• Stereochemistry
• R, S- or P, M-Nomenclature of organic compounds
• Biaryls and allenes
• Asymmetric synthesis
• Pericyclic reactions
• Proteins – classification, structure and properties
• Molecular weight determination
• Isoelectric point
• Coagulation and denaturation
• Carbohydrates – classification, structure and reactions
• Fats and lipids – classification, structure and reactions
• Alkaloids – classification, isolation and identification

Unit-VIII: Narcotic Drugs & Psychotropic Substances

• Definition, types, appearance, production and chemical characteristics of narcotic drugs and psychotropic substances
• Designer drugs
• Mode of administration
• Pharmacological action
• Biotransformation
• Common terminology of drugs of forensic importance
• Sampling methods
• Extraction and isolation
• Qualitative and quantitative analytical techniques
• Plants of narcotic importance and their morphology
• Papaver somniferum
• Cannabis sativa
• Coca plant
• Analysis of active constituents
• Controlled substances and their classification
• Precursor chemicals
• Narcotic raids
• Clandestine drug laboratory evidence and forensic examination
• New Psychotropic Substances (NPS)
• Pharmacology and toxicology of NPS
• UN conventions and legislation
• Extraction, isolation and identification of alkaloids including morphine, codeine, brucine, strychnine, nicotine, atropine, hyoscyamine, cocaine, heroin and Dhatura alkaloids
• Analysis of sedatives, depressants, stimulants, opiates and drugs of abuse
• Provisions under Drugs Act, Excise Act and NDPS Act

Unit-IX: Forensic Chemistry

• Introduction to forensic chemistry
• Preliminary and confirmatory methods
• Identification schemes for unknown solids
• Volumetric and titrimetric methods
• Theory of indicators
• Precipitation process
• Saturated and unsaturated solutions
• Sample preparation in organic and inorganic analytical chemistry
• Phenolphthalein in bribe trap cases
• Related legal issues
• Corrosive chemicals including hydrochloric acid, sulphuric acid and nitric acid
• Alkalis in acid/alkali throwing cases

Arson: Chemistry of fire, scientific investigation, evaluation of clue materials, collection and preservation, and analysis of flammable residues.

Petroleum Products:

• Properties and testing of petroleum and petroleum products
• Adulteration in petroleum products
• Analysis of petrol, kerosene, diesel, lubricating oil, furnace oil and grease as per BIS specifications
• Analysis of dyes used in petroleum products
• Chemical fingerprinting of petroleum products

Alcohol:

• Country-made liquor
• Illicit liquor
• Rectified spirit
• Proof spirit
• Absolute alcohol
• Signs and symptoms of alcohol intoxication
• Effects of alcohol on the body
• Methanol poisoning
• Sample collection and analysis
• Specific gravity method
• Breath-alcohol instrumentation
• Alcohol measurement in blood, breath, urine, saliva and oral fluids

Unit-X: Analytical Chemistry & Biochemical Analysis

• Classical and instrumental analytical methods
• Volumetric, titrimetric and gravimetric techniques
• Selection of analytical techniques
• Range of determination
• Accuracy, precision and errors
• Sample preparation
• Safe handling of reagents
• Density and viscosity measurements
• Good Laboratory Practices
• Standard Operating Procedures
• Quality assurance and quality control
• Analytical method validation

General Principles of Biological/Biochemical Analysis:

• pH and buffers
• Physiological solution
• Centrifugation techniques
• Basic principle of sedimentation
• Various types of centrifuges
• Density gradient centrifugation
• Preparative centrifugation
• Analysis of sub-cellular fractions
• Ultracentrifuge
• Refrigerated centrifuges

Unit-XI: Sample Preparation & Separation Techniques

• Liquid-liquid extraction and solvent extraction
• Partition coefficient
• Distribution ratio
• Percentage extraction
• Solvent extraction of metal ions
• Ion association complexes and metal chelates
• Multiple batch extraction
• Craig’s counter-current distribution
• Accelerated and microwave-assisted extraction
• Protein precipitation
• Solid Phase Extraction (SPE)

Separation Techniques:

• Partition chromatography
• Adsorption chromatography
• Ion exchange chromatography
• Size exclusion chromatography

Emerging and Hyphenate Techniques:

• Gas Chromatography – Head Space
• Inductively Coupled Plasma-Mass Spectroscopy
• X-Ray Spectroscopy
• Gas Chromatography-Mass Spectroscopy (GC-MS)
• GC-MS-MS (Tandem)
• Liquid Chromatography-Mass Spectroscopy (LC-MS)
• LC-MS-MS (Tandem)
• Capillary Chromatography

Extraction and purification of drugs/poisons from biological samples:

• Extraction of volatile compounds
• Extraction of neutral non-volatile compounds
• Extraction of acidic and basic non-volatile compounds
• Extraction from viscera, blood, urine, hair and saliva
• Stas-Otto method
• Dovrijey-Nickolls method
• Acid digestion method
• Valov method

Unit-XII: Forensic Pharmacology

• Concept of pharmacology
• Basic concepts of pharmacokinetics
• Absorption and first-pass metabolism
• Bioavailability
• Distribution
• Elimination and drug half-life
• Excretion
• Drug metabolism
• Phase-I and Phase-II conjugation reactions
• Metabolism of benzodiazepines
• Metabolism of barbiturates
• Metabolism of amphetamines
• Metabolism of heroin, codeine and morphine
• Detection of metabolites
• Factors affecting pharmacokinetics
• Pharmacodynamics and pharmacogenesis

Drug Development Process:

• Methods involved in development of new drugs
• Preclinical toxicological studies
• Calculation of LD50 and ED50
• Acute, subacute and chronic toxicity studies
• Irwin profile test
• Preclinical pharmacokinetic and pharmacodynamic studies
• Lipinski’s rule for drug-like molecules
• High-throughput screening (in vitro and in vivo)

Important Topics for HPPSC Scientific Officer (NDPS) Preparation

Candidates preparing for the HPPSC Scientific Officer (NDPS) examination should give special attention to the major technical areas included in the official syllabus. These include:

• Forensic Science principles and evidence
• Crime scene investigation and reconstruction
• Blood stain pattern analysis
• Fingerprint science and NAFIS
• Microscopy and spectroscopy
• Chromatography and electrophoresis
• Chemometrics and statistical analysis
• Quality management and ISO standards
• Forensic laws and expert testimony
• Organic and analytical chemistry
• Narcotic drugs and psychotropic substances
• Forensic chemistry
• Petroleum products and alcohol analysis
• Sample extraction and separation techniques
• GC-MS, LC-MS and related hyphenate techniques
• Forensic pharmacology and drug metabolism

HPPSC Scientific Officer (NDPS) Syllabus PDF

Candidates are advised to study the syllabus carefully and prepare each unit systematically. The uploaded HPPSC syllabus specifies the complete subject coverage for the Descriptive Subject Aptitude Test and confirms the 3-hour, 120-mark examination structure.

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